Voltage and ion dependences of the slow currents which mediate bursting in Aplysia neurone R15.
نویسندگان
چکیده
منابع مشابه
A cyclic GMP analog decreases the currents underlying bursting activity in the Aplysia neuron R15.
Bath application of 8-parachlorophenylthio-cyclic GMP (8-pcpt-cGMP) has been shown to increase the number of action potentials per burst in the Aplysia neuron R15. Here we report that 8-pcpt-cGMP can eventually inhibit R15's bursting activity and cause the cell to exhibit slow tonic spiking activity. This action is preceded by decreases in spike frequency and in the amplitude of the interburst ...
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1. An equivalent circuit model of the R15 bursting neuron in Aplysia has been combined with a fluid compartment model, resulting in a model that incorporates descriptions of most of the membrane ion channels that are known to exist in the somata of R15, as well as providing a Ca2+ balance on the cell. 2. A voltage-activated, calcium-inactivated Ca2+ current (denoted the slow inward current ISI)...
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The identified neurone R15 in the abdominal ganglion of the marine mollusc, Aplysia californica, exhibits a rhythmic bursting pattern of electrical activity. This pattern, which is generated endogenously by the interaction of several voltage- and time-dependent ion currents in R15's membrane, is subject to long-term modulation by synaptic stimulation and application of several neurotransmitters...
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Editor's Note: These short, critical reviews of recent papers in the Journal, written exclusively by graduate students or postdoctoral fellows, are intended to summarize the important findings of the paper and provide additional insight and commentary. For more information on the format and purpose of the Journal Club, please see A growing body of work, primarily using invertebrate systems, has...
متن کاملDopamine reduces slow outward current and calcium influx in burst-firing neuron R15 of Aplysia.
Dopamine's effect on calcium influx into the bursting neuron, R15, of Aplysia californica was tested by tail current measurements and by measurement of absorbance of intracellular Arsenazo III, a calcium-sensitive indicator. Slow outward tail currents were elicited by subthreshold depolarization in voltage clamp and were demonstrated to be dependent upon transient increases in intracellular cal...
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ژورنال
عنوان ژورنال: The Journal of Physiology
سال: 1985
ISSN: 0022-3751
DOI: 10.1113/jphysiol.1985.sp015604